Kanye West has been a target for years when it comes to South Park creators Trey Parker and Matt Stone. Just last week, during the preview of the TV show's upcoming video game, South Park: The Fractured But Whole, at E3 in Los Angeles, Stone and Parker decided to take aim at Kanye once again and poke fun of the MC's upcoming video game Only One.

When asked to describe the concept of South Park's forthcoming video game, Parker jokingly responded, "There’s a gay fish in South Park, and he loves fish sticks, and the gay fish actually wants you to help him get his mother into heaven, so you get to journey up and help this little gay fish get his mom into heaven.”

If you recall, "gay fish" is a reference used by the South Park characters in a 2009 episode that centered around Kanye West and his antics.

While Kanye West has served as the butt of jokes for a few of South Park's episodes, he's not the only hip-hop artist to appear on the popular animated cartoon. In the past, the TV franchise has featured the likes of Diddy, Eminem and the late Tupac Shakur and The Notorious B.I.G. With hip-hop becoming such a strong force in the world of entertainment, we're sure South Park will end up taking jabs and poking fun at other hip-hop acts.

With the most recent shots from the South Park creators towards Kanye, XXL looks back at the five appears that have appeared on the popular American TV show.